The Intestinal Adaptation Laboratory at St. Louis Children’s Hospital seeks to understand the mechanisms through which the intestine adapts to massive intestinal loss. Specific research themes currently being investigated:

  • The role for retinoblastoma protein in the genesis of intestinal resection-induced enterocyte proliferation
  • The effects of intestinal resection on the intestinal microbiome
  • The contributions of intestinal angiogenesis to gut adaptation
  • The link between insulin-like growth factor-1 (IGF1) signaling within the subepithelial mesenchyme as a stimulus for intestinal regeneration

In the area of congenital diaphragmatic hernias, Washington University Medical Center/SLCH is one of seven centers participating in the DHREAMS (Diaphragmatic Hernia Research & Exploration; Advancing Molecular Science) study at Columbia University Medical Center in New York City, which seeks to improve understanding of the molecular genetic basis of CDH. SLCH also is a contributing center to the National Congenital Diaphragmatic Hernia Database, which is housed at the University of Texas Medical School at Houston.

Jacqueline Saito, MD, is exploring the area of optimal imaging for children with abdominal pain. She is also the institutional champion for the Pediatric National Quality Surgical Improvement Project – focused on improving outcomes for pediatric surgical disease. She is also the institutional PI for a multicenter, prospective trial designed to determine optimal timing for repair of inguinal hernia in premature infants.

Martin Keller, MD, is the director of our American College of Surgeons certified – Level One Trauma Center. In this role, he is leading multiple trauma-related epidemiologic clinical studies. He is also director of the Chest Wall Deformity Program.

Patrick Dillon, MD, is the surgical PI for the multicenter Biliary Atresia Research Consortium.

Learn more about research in the Division of Pediatric Surgery.